|
UniProt seq
|
|||||
|
PIM2_HUMAN_D0
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
L
T
K
P
L
Q
G
P
P
A
P
P
G
T
P
T
P
P
P
G
G
K
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
G
W
S
P
L
S
D
S
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
T
Q
E
G
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
P
A
E
D
V
P
L
N
P
S
K
G
G
P
A
P
L
A
W
S
L
L
P
-
|
||||
|
Plasmids
|
nconf
|
nextran
|
|||
|
23587
|
0
|
56
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
L
T
K
P
L
Q
G
P
P
A
P
P
G
T
P
T
P
P
P
G
G
K
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
G
W
S
P
L
S
D
S
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
T
Q
E
G
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
P
A
E
D
V
P
L
N
P
S
K
G
G
P
A
P
L
A
W
S
L
L
P
-
|
||
|
HsCD00038668
|
0
|
57
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
M
L
T
K
P
L
Q
G
P
P
A
P
P
G
T
P
T
P
P
P
G
G
K
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
G
W
S
P
L
S
D
S
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
T
Q
E
G
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
P
A
E
D
V
P
L
N
P
S
K
G
G
P
A
P
L
A
W
S
L
L
P
l
|
||
|
PIM2A-c007
|
0
|
78
|
m
h
h
h
h
h
h
s
s
g
v
d
l
g
t
e
n
l
y
f
q
s
M
L
T
K
P
L
Q
G
P
P
A
P
P
G
T
P
T
P
P
P
G
G
K
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
G
W
S
P
L
S
D
S
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
T
Q
E
G
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
P
A
E
D
V
P
L
N
P
S
K
G
G
P
A
P
L
A
W
S
L
L
P
-
|
||
|
PDB constructs
|
nconf
|
nextran
|
expr_tag
|
organism
|
|
|
2IWI_A
|
0
|
58
|
Human
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
s
M
L
T
K
P
L
Q
G
P
P
A
P
P
G
T
P
T
P
P
P
G
G
K
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
G
W
S
P
L
S
D
S
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
T
Q
E
G
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
P
A
E
D
V
P
L
N
P
S
K
G
G
P
A
P
L
A
W
S
L
L
P
-
|
|
|
2IWI_B
|
0
|
58
|
Human
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
s
M
L
T
K
P
L
Q
G
P
P
A
P
P
G
T
P
T
P
P
P
G
G
K
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
G
W
S
P
L
S
D
S
V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
T
Q
E
G
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
P
A
E
D
V
P
L
N
P
S
K
G
G
P
A
P
L
A
W
S
L
L
P
-
|