|
UniProt seq
|
|||||
|
CDK6_HUMAN_D0
|
M
E
K
D
G
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
C
K
E
N
L
D
S
H
L
P
P
S
Q
N
T
S
E
L
N
T
A
-
|
||||
|
Tested construct
|
|||||
|
|
M
E
K
D
G
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
|
||||
|
Plasmids
|
nconf
|
nextran
|
|||
|
addgene/23688
|
0
|
38
|
M
E
K
D
G
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
C
K
E
N
L
D
S
H
L
P
P
S
Q
N
T
S
E
L
N
T
A
-
|
||
|
HIP/HsCD00038347
|
0
|
38
|
M
E
K
D
G
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
C
K
E
N
L
D
S
H
L
P
P
S
Q
N
T
S
E
L
N
T
A
-
|
||
|
HIP/HsCD00037976
|
0
|
39
|
M
E
K
D
G
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
C
K
E
N
L
D
S
H
L
P
P
S
Q
N
T
S
E
L
N
T
A
l
|
||
|
PDB constructs
|
nconf
|
nextran
|
expr_tag
|
organism
|
|
|
4EZ5_A
|
0
|
20
|
Histag_Cterm
|
Human
|
M
E
K
D
G
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
h
h
h
h
h
h
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
|
|
1XO2_B
|
0
|
21
|
Human
|
M
E
K
D
G
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
F
D
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
P
E
P
G
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
Q
A
F
H
S
K
S
A
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
C
K
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
|